Two possible suspects have been detained after a deadly afternoon shooting in downtown Denver.

Police say an altercation around 2:30 p.m. in a parking lot in the 1600 block of Champa Street led to a shooting that killed one man.

The identities of the suspects and victims are still unclear, but police say both victims were male. One man was pronounced dead at the hospital, but the other victim's condition is unknown at this time.

The possible suspects in this shooting were detained after boarding an RTD bus.

Champa is closed from 17th to 19th while police investigate. Drivers are urged to avoid this area.

Police say the increased amount if officers on the 16th Street Mall helped aid the investigation.

9NEWS has a crew on the scene and will update this as more information is available.