FOXBOROUGH, Mass. (AP) - Jeff Wilson Jr. rushed for a career-high three touchdowns and 112 yards before leaving the game with an ankle injury and the San Francisco 49ers dominated the New England Patriots in a 33-6 win.
Jimmy Garoppolo finished 20 of 25 for 277 yards with two interceptions in his first game against his former team.
San Francisco has followed back-to-back losses with two wins.
Brandon Aiyuk had six catches for 115 yards.
New England fell to 2-4 for the first time since coach Bill Belichick’s first season in 2000.